AustralieFrV1, Main, Exploration, bibRecord, 00AA68

Targeted anticytokine therapy in patients with chronic Heart failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)

Identifieur interne : 00AA68 ( Main/Exploration ); précédent : 00AA67; suivant : 00AA69

Targeted anticytokine therapy in patients with chronic Heart failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)

Auteurs : Douglas L. Mann [États-Unis] ; John J. V. Mcmurray [Royaume-Uni] ; Milton Packer [États-Unis] ; Karl Swedberg [Suède] ; Jeffrey S. Borer [États-Unis] ; Wilson S. Colucci [France] ; Jacques Djian [France] ; Helmut Drexler [Allemagne] ; Arthur Feldman [États-Unis] ; Lars Kober [Danemark] ; Henry Krum [Australie] ; Peter Liu [Canada] ; Markku Nieminen [Finlande] ; Luigi Tavazzi [Italie] ; Dirk Jan Van Veldhuisen [Pays-Bas] ; Anders Waldenstrom [Suède] ; Marshelle Warren [États-Unis] ; Arne Westheim [Norvège] ; Faiez Zannad [France] ; Thomas Fleming [États-Unis]

Source :

Circulation : (New York, N.Y.) [ 0009-7322 ] ; 2004.

RBID : Pascal:04-0227449

Descripteurs français

Pascal (Inist)
- Insuffisance cardiaque, Traitement, Homme, Appareil circulatoire pathologie, Etanercept.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cardiovascular disease, Etanercept, Heart failure, Human, Treatment.

Abstract

Background-Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure. Methods and Results-Patients with New York Heart Association class II to IV chronic heart failure and a left ventricular ejection fraction ≤0.30 were enrolled in 2 clinical trials that differed only in the doses of etanercept used. In RECOVER, patients received placebo (n=373) or subcutaneous etanercept in doses of 25 mg every week (n=375) or 25 mg twice per week (n=375). In RENAISSANCE, patients received placebo (n=309), etanercept 25 mg twice per week (n=308), or etanercept 25 mg 3 times per week (n=308). The primary end point of each individual trial was clinical status at 24 weeks. Analysis of the effect of the 2 higher doses of etanercept on the combined outcome of death or hospitalization due to chronic heart failure from the 2 studies was also planned (RENEWAL). On the basis of prespecified stopping rules, both trials were terminated prematurely owing to lack of benefit. Etanercept had no effect on clinical status in RENAISSANCE (P=0.17) or RECOVER (P=0.34) and had no effect on the death or chronic heart failure hospitalization end point in RENEWAL (etanercept to placebo relative risk=1.1, 95% Cl 0.91 to 1.33, P=0.33). Conclusions-The results of RENEWAL rule out a clinically relevant benefit of etanercept on the rate of death or hospitalization due to chronic heart failure.

Affiliations:

Allemagne, Australie, Canada, Danemark, Finlande, France, Italie, Norvège, Pays-Bas, Royaume-Uni, Suède, États-Unis
Basse-Saxe, Washington (État), Île-de-France, Østlandet
Hanovre, Oslo, Paris, Seattle
Université de Washington

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Targeted anticytokine therapy in patients with chronic Heart failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)</title>
<author><name sortKey="Mann, Douglas L" sort="Mann, Douglas L" uniqKey="Mann D" first="Douglas L." last="Mann">Douglas L. Mann</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA</s1>
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<author><name sortKey="Mcmurray, John J V" sort="Mcmurray, John J V" uniqKey="Mcmurray J" first="John J. V." last="Mcmurray">John J. V. Mcmurray</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiology, Western Infirmary</s1>
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<author><name sortKey="Packer, Milton" sort="Packer, Milton" uniqKey="Packer M" first="Milton" last="Packer">Milton Packer</name>
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<author><name sortKey="Swedberg, Karl" sort="Swedberg, Karl" uniqKey="Swedberg K" first="Karl" last="Swedberg">Karl Swedberg</name>
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<author><name sortKey="Kober, Lars" sort="Kober, Lars" uniqKey="Kober L" first="Lars" last="Kober">Lars Kober</name>
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<author><name sortKey="Nieminen, Markku" sort="Nieminen, Markku" uniqKey="Nieminen M" first="Markku" last="Nieminen">Markku Nieminen</name>
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<s2>Haartmaninkatu, Helsinki</s2>
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<author><name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name>
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</inist:fA14>
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<author><name sortKey="Van Veldhuisen, Dirk Jan" sort="Van Veldhuisen, Dirk Jan" uniqKey="Van Veldhuisen D" first="Dirk Jan" last="Van Veldhuisen">Dirk Jan Van Veldhuisen</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Academisch Ziekenhuis Groningen, Cardio Research</s1>
<s2>GZ Groningen</s2>
<s3>NLD</s3>
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</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>GZ Groningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waldenstrom, Anders" sort="Waldenstrom, Anders" uniqKey="Waldenstrom A" first="Anders" last="Waldenstrom">Anders Waldenstrom</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Medicine, Umea University Hospital</s1>
<s2>Umea</s2>
<s3>SWE</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Umea</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Warren, Marshelle" sort="Warren, Marshelle" uniqKey="Warren M" first="Marshelle" last="Warren">Marshelle Warren</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Amgen Inc</s1>
<s2>Thousand Oaks, Calif.</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Amgen Inc</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Westheim, Arne" sort="Westheim, Arne" uniqKey="Westheim A" first="Arne" last="Westheim">Arne Westheim</name>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Medicinsk Klinikk, Hjertemedisinsk Avd</s1>
<s2>Ulleval Sykehus, Oslo</s2>
<s3>NOR</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Norvège</country>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Centre d'Investigation Clinique, Hopital Jeanne d'Arc</s1>
<s2>Dommartin Les Toul</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Dommartin Les Toul</wicri:noRegion>
<wicri:noRegion>Hopital Jeanne d'Arc</wicri:noRegion>
<wicri:noRegion>Dommartin Les Toul</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fleming, Thomas" sort="Fleming, Thomas" uniqKey="Fleming T" first="Thomas" last="Fleming">Thomas Fleming</name>
<affiliation wicri:level="4"><inist:fA14 i1="20"><s1>Department of Biostatistics, University of Washington</s1>
<s2>Seattle, Wash.</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Circulation : (New York, N.Y.)</title>
<title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title>
<idno type="ISSN">0009-7322</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Circulation : (New York, N.Y.)</title>
<title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title>
<idno type="ISSN">0009-7322</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiovascular disease</term>
<term>Etanercept</term>
<term>Heart failure</term>
<term>Human</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Insuffisance cardiaque</term>
<term>Traitement</term>
<term>Homme</term>
<term>Appareil circulatoire pathologie</term>
<term>Etanercept</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background-Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure. Methods and Results-Patients with New York Heart Association class II to IV chronic heart failure and a left ventricular ejection fraction ≤0.30 were enrolled in 2 clinical trials that differed only in the doses of etanercept used. In RECOVER, patients received placebo (n=373) or subcutaneous etanercept in doses of 25 mg every week (n=375) or 25 mg twice per week (n=375). In RENAISSANCE, patients received placebo (n=309), etanercept 25 mg twice per week (n=308), or etanercept 25 mg 3 times per week (n=308). The primary end point of each individual trial was clinical status at 24 weeks. Analysis of the effect of the 2 higher doses of etanercept on the combined outcome of death or hospitalization due to chronic heart failure from the 2 studies was also planned (RENEWAL). On the basis of prespecified stopping rules, both trials were terminated prematurely owing to lack of benefit. Etanercept had no effect on clinical status in RENAISSANCE (P=0.17) or RECOVER (P=0.34) and had no effect on the death or chronic heart failure hospitalization end point in RENEWAL (etanercept to placebo relative risk=1.1, 95% Cl 0.91 to 1.33, P=0.33). Conclusions-The results of RENEWAL rule out a clinically relevant benefit of etanercept on the rate of death or hospitalization due to chronic heart failure.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>Finlande</li>
<li>France</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Basse-Saxe</li>
<li>Washington (État)</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement><li>Hanovre</li>
<li>Oslo</li>
<li>Paris</li>
<li>Seattle</li>
</settlement>
<orgName><li>Université de Washington</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Mann, Douglas L" sort="Mann, Douglas L" uniqKey="Mann D" first="Douglas L." last="Mann">Douglas L. Mann</name>
</noRegion>
<name sortKey="Borer, Jeffrey S" sort="Borer, Jeffrey S" uniqKey="Borer J" first="Jeffrey S." last="Borer">Jeffrey S. Borer</name>
<name sortKey="Feldman, Arthur" sort="Feldman, Arthur" uniqKey="Feldman A" first="Arthur" last="Feldman">Arthur Feldman</name>
<name sortKey="Fleming, Thomas" sort="Fleming, Thomas" uniqKey="Fleming T" first="Thomas" last="Fleming">Thomas Fleming</name>
<name sortKey="Packer, Milton" sort="Packer, Milton" uniqKey="Packer M" first="Milton" last="Packer">Milton Packer</name>
<name sortKey="Warren, Marshelle" sort="Warren, Marshelle" uniqKey="Warren M" first="Marshelle" last="Warren">Marshelle Warren</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Mcmurray, John J V" sort="Mcmurray, John J V" uniqKey="Mcmurray J" first="John J. V." last="Mcmurray">John J. V. Mcmurray</name>
</noRegion>
</country>
<country name="Suède"><noRegion><name sortKey="Swedberg, Karl" sort="Swedberg, Karl" uniqKey="Swedberg K" first="Karl" last="Swedberg">Karl Swedberg</name>
</noRegion>
<name sortKey="Waldenstrom, Anders" sort="Waldenstrom, Anders" uniqKey="Waldenstrom A" first="Anders" last="Waldenstrom">Anders Waldenstrom</name>
</country>
<country name="France"><noRegion><name sortKey="Colucci, Wilson S" sort="Colucci, Wilson S" uniqKey="Colucci W" first="Wilson S." last="Colucci">Wilson S. Colucci</name>
</noRegion>
<name sortKey="Djian, Jacques" sort="Djian, Jacques" uniqKey="Djian J" first="Jacques" last="Djian">Jacques Djian</name>
<name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name>
</country>
<country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Drexler, Helmut" sort="Drexler, Helmut" uniqKey="Drexler H" first="Helmut" last="Drexler">Helmut Drexler</name>
</region>
</country>
<country name="Danemark"><noRegion><name sortKey="Kober, Lars" sort="Kober, Lars" uniqKey="Kober L" first="Lars" last="Kober">Lars Kober</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name>
</noRegion>
</country>
<country name="Canada"><noRegion><name sortKey="Liu, Peter" sort="Liu, Peter" uniqKey="Liu P" first="Peter" last="Liu">Peter Liu</name>
</noRegion>
</country>
<country name="Finlande"><noRegion><name sortKey="Nieminen, Markku" sort="Nieminen, Markku" uniqKey="Nieminen M" first="Markku" last="Nieminen">Markku Nieminen</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name>
</noRegion>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Van Veldhuisen, Dirk Jan" sort="Van Veldhuisen, Dirk Jan" uniqKey="Van Veldhuisen D" first="Dirk Jan" last="Van Veldhuisen">Dirk Jan Van Veldhuisen</name>
</noRegion>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Westheim, Arne" sort="Westheim, Arne" uniqKey="Westheim A" first="Arne" last="Westheim">Arne Westheim</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Targeted anticytokine therapy in patients with chronic Heart failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)

Targeted anticytokine therapy in patients with chronic Heart failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)

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